Global Multiple Sequence Alignment
نویسنده
چکیده
As with pairwise alignment, multiple sequence alignments (MSAs) are typically scored by assigning a score to each column and summing over the columns. The most common approach to scoring individual columns in a multiple alignment is to calculate a score for each pair of symbols in the column, and then sum over the pair scores. This is called sum-of-pairs or SP-scoring. For global multiple sequence alignment, SP-scoring can be used with either a distance metric or a similarity scoring function. The sum-of-pairs similarity score of an alignment of k sequences is
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